More Clinical Data Required to Support European Approval of CAP Indication for TYGACIL
24/04/2008 00:04
PR Newswire
COLLEGEVILLE, Pennsylvania, April 23 /PRNewswire/ --
- Wyeth Withdraws European Application
Wyeth Pharmaceuticals, a division of Wyeth (NYSE: WYE), announced today
that it is withdrawing its application for an extension to the European
Marketing Authorization for TYGACIL(R) (tigecycline). This extension sought
approval of TYGACIL for the treatment of community-acquired pneumonia (CAP).
Wyeth's action is based on its understanding of the Committee for Medicinal
Products for Human Use (CHMP) assessment that the TYGACIL CAP pivotal
clinical trials did not include a sufficient number of severely ill CAP
patients to alleviate reviewer concerns regarding efficacy in this
subpopulation. TYGACIL is currently approved in Europe for the treatment of
complicated intra-abdominal infections and complicated skin and soft tissue
infections in adults.
"We are disappointed that we were not able to allay the concerns of the
CHMP, and are evaluating the appropriate next steps to take in Europe," says
Gary L. Stiles, M.D., Executive Vice President and Chief Medical Officer,
Wyeth Pharmaceuticals. "In October 2007, the U.S. Food and Drug
Administration (FDA) accepted the filing of our supplemental New Drug
Application for TYGACIL for the treatment of patients with CAP. We believe
that the clinical trial data submitted to the FDA, as well as other
regulatory authorities around the world, demonstrate the safety and efficacy
of TYGACIL for the proposed CAP indication."
The FDA is currently reviewing this application and a decision is
expected during the second quarter of 2008. TYGACIL has been approved for use
in patients with CAP in the Philippines and Thailand. Regulatory applications
are also pending in Australia, Brazil, Canada, Switzerland and India.
Indications
TYGACIL(R) (tigecycline) is indicated for the treatment of adults with:
-- Complicated skin and skin structure infections caused by Escherichia
coli, Enterococcus faecalis (vancomycin-susceptible isolates only),
Staphylococcus aureus (methicillin-susceptible and -resistant
isolates), Streptococcus agalactiae, Streptococcus anginosus group
(includes S. anginosus, S. intermedius, and S. constellatus),
Streptococcus pyogenes, and Bacteroides fragilis
-- Complicated intra-abdominal infections caused by Citrobacter freundii,
Enterobacter cloacae, Escherichia coli, Klebsiella oxytoca, Klebsiella
pneumoniae, Enterococcus faecalis (vancomycin-susceptible isolates
only), Staphylococcus aureus (methicillin-susceptible isolates only),
Streptococcus anginosus group (includes S. anginosus, S. intermedius,
and S. constellatus), Bacteroides fragilis, Bacteroides
thetaiotaomicron, Bacteroides uniformis, Bacteroides vulgatus,
Clostridium perfringens, and Peptostreptococcus micros
Important Safety Information
-- To reduce the development of drug-resistant bacteria and maintain the
effectiveness of TYGACIL and other antibacterial drugs, TYGACIL should
be used only to treat infections proven or strongly suspected to be
caused by susceptible bacteria
-- Anaphylaxis/anaphylactoid reactions have been reported with nearly all
antibacterial agents, including tigecycline, and may be life-
threatening
-- TYGACIL is contraindicated in patients with known hypersensitivity to
tigecycline
-- TYGACIL should be administered with caution in patients with known
hypersensitivity to tetracycline class antibiotics
-- Glycylcycline class antibiotics are structurally similar to
tetracycline class antibiotics and may have similar adverse effects.
Such effects may include: photosensitivity, pseudotumor cerebri, and
anti-anabolic action (which has led to increased BUN, azotemia,
acidosis, and hyperphosphatemia). As with tetracyclines, pancreatitis
has been reported with the use of TYGACIL
-- The safety and efficacy of TYGACIL in patients with hospital-acquired
pneumonia have not been established
-- In clinical trials, the most common treatment-emergent adverse events
in patients treated with TYGACIL were nausea (29.5%) and vomiting
(19.7%)
-- TYGACIL may cause fetal harm when administered to a pregnant woman
-- The safety and effectiveness of TYGACIL in patients below age 18 and
lactating women have not been established
-- Clostridium difficile-associated diarrhea (CDAD) has been reported with
use of nearly all antibacterial agents, including TYGACIL, and may
range in severity from mild diarrhea to fatal colitis
-- Concurrent use of antibacterial drugs with oral contraceptives may
render oral contraceptives less effective
-- The use of TYGACIL during tooth development may cause permanent
discoloration of the teeth. TYGACIL should not be used during tooth
development unless other drugs are not likely to be effective or are
contraindicated
-- Prothrombin time or other suitable anticoagulant test should be
monitored if TYGACIL is administered with warfarin
-- Monotherapy should be used with caution in patients with clinically
apparent intestinal perforation
-- In patients with severe hepatic impairment (Child Pugh C), the initial
dose of TYGACIL should be 100 mg followed by 25 mg every 12 hours.
Patients should be treated with caution and monitored for treatment
response
-- The following drugs should not be administered simultaneously through
the same Y-site as TYGACIL: amphotericin B and diazepam
Please see Prescribing Information.
Wyeth Pharmaceuticals:
Wyeth Pharmaceuticals, a division of Wyeth has leading products in the
areas of women's health care, infectious disease, gastrointestinal health,
central nervous system, inflammation, transplantation, hemophilia, oncology,
vaccines and nutritional products.
Wyeth is one of the world's largest research-driven pharmaceutical and
health care products companies. It is a leader in the discovery, development,
manufacturing and marketing of pharmaceuticals, vaccines, biotechnology
products, nutritionals and non-prescription medicines that improve the
quality of life for people worldwide. The Company's major divisions include
Wyeth Pharmaceuticals, Wyeth Consumer Healthcare and Fort Dodge Animal
Health.
The statements in this press release that are not historical facts are
forward-looking statements that are subject to risks and uncertainties that
could cause actual results to differ materially from those expressed or
implied by such statements. These risks and uncertainties include, without
limitation, the inherent uncertainty of the timing and success of, and
expense associated with, research, development, regulatory approval and
commercialization of our products and pipeline products; government
cost-containment initiatives; restrictions on third-party payments for our
products; substantial competition in our industry, including from branded and
generic products; emerging data on our products and pipeline products; the
importance of strong performance from our principal products and our
anticipated new product introductions; the highly regulated nature of our
business; product liability, intellectual property and other litigation risks
and environmental liabilities; uncertainty regarding our intellectual
property rights and those of others; difficulties associated with, and
regulatory compliance with respect to, manufacturing of our products; risks
associated with our strategic relationships; economic conditions including
interest and currency exchange rate fluctuations; changes in generally
accepted accounting principles; trade buying patterns; the impact of
legislation and regulatory compliance; risks and uncertainties associated
with global operations and sales; and other risks and uncertainties,
including those detailed from time to time in our periodic reports filed with
the Securities and Exchange Commission, including our current reports on Form
8-K, quarterly reports on Form 10-Q and annual report on Form 10-K,
particularly the discussion under the caption "Item 1A, Risk Factors" in our
Annual Report on Form 10-K for the year ended December 31, 2007, which was
filed with the Securities and Exchange Commission on February 29, 2008. The
forward-looking statements in this press release are qualified by these risk
factors. We assume no obligation to publicly update any forward-looking
statements, whether as a result of new information, future developments or
otherwise.
Web site: http://www.wyeth.com
Media Contacts: Sal Foti, Wyeth Pharmaceuticals, +1-484-865-3490, or Douglas Petkus, Wyeth, +1-973-660-5218; or Investor Contact: Justin Victoria, Wyeth, +1-973-660-5340